Blar i forfatter "Ehlers, Bernhard"

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    • Identification of a Novel Human Polyomavirus in Organs of the Gastrointestinal Tract 

      Korup, Sarah; Rietscher, Janita; Calvignac-Spencer, Sébastien; Trusch, Franziska; Hofmann, Jörg; Moens, Ugo; Sauer, Igor; Voigt, Sebastien; Schmuck, Rosa; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Polyomaviruses are small, non-enveloped viruses with a circular double-stranded DNA genome. Using a generic polyomavirus PCR targeting the VP1 major structural protein gene, a novel polyomavirus was initially identified in resected human liver tissue and provisionally named Human Polyomavirus 12 (HPyV12). Its 5033 bp genome is predicted to encode large and small T antigens and the 3 structural ...

    • Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population 

      Scuda, Nelly; Madinda, Nadege; Akoua-Koffi, Chantal; Adjogoua, Edgard V; Wevers, Diana; Hofmann, Jörg; Cameron, Kenneth M.; Leendertz, Siv Aina Jensen; Couacy-Hymann, Emmanuel; Robbins, Martha M.; Boesch, Christophe; Jarvis, Michael; Moens, Ugo; Calvignac-Spencer, Sébastien; Leendertz, Fabian H; Ehlers, Bernhard; Ehlers, B (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Polyomaviruses are a family of small non-enveloped DNA viruses that encode oncogenes and have been associated, to greater or lesser extent, with human disease and cancer. Currently, twelve polyomaviruses are known to circulate within the human population. To further examine the diversity of human polyomaviruses, we have utilized a combinatorial approach comprised of initial degenerate primer-based ...

    • Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line. 

      Abdulsalam, Ibrahim Afolabi; Rasheed, Kashif; Sveinbjørnsson, Baldur; Ehlers, Bernhard; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-19)
      <p><i>Background - </i>Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. Several MCPyV variants with polymorphism in their promoter region have been isolated, but it ...

    • A role of Sp1 binding motifs in basal and large T-Antigen-induced promoter activities of human polyomavirus HPyV9 and its variant UF-1 

      Moens, Ugo; Song, Xiaobo; Van Ghelue, Marijke; Lednicky, John A.; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-14)
      Human polyomavirus 9 (HPyV9) was originally detected in the serum of a renal transplant patient. Seroepidemiological studies showed that ~20-50% of the human population have antibodies against this virus. HPyV9 has not yet been associated with any disease and little is known about the route of infection, transmission, host cell tropism, and genomic variability in circulating strains. Recently, the ...

    • A taxonomy update for the Family Polyomaviridae 

      Calvignac-Spencer, Sébastien; Feltkamp, Mariet CW; Daugherty, Matthew D; Moens, Ugo; Ramqvist, Torbjörn; Johne, Reimar; Ehlers, Bernhard (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)
      Many distinct polyomaviruses infecting a variety of vertebrate hosts have recently been discovered, and their complete genome sequence could often be determined. To accommodate this fast-growing diversity, the International Committee on Taxonomy of Viruses (ICTV) <i>Polyomaviridae</i> Study Group designed a host- and sequence-based rationale for an updated taxonomy of the family <i>Polyomaviridae</i>. ...